Foley was born in Kansas City, Kansas, the first of three boys for Connie and Hugh Foley. His father was an international banker, and the family lived in Japan and Australia during Foley's childhood. The family settled in St. Louis, Missouri when Scott was 15 years old. His mother died from ovarian cancer when he was a teenager. Foley attended Ladue High School, before graduating from Clayton High School.
Foley's breakthrough role was playing Noel Crane on Felicity. Foley has had recurring guest appearances on Scrubs as Elliot Reid's boyfriend, Sean Kelly, and on Dawson's Creek as Cliff Elliot.
Foley was nominated for a Teen Choice Award for Choice Movie Villain for his role in Scream 3. Aside from acting, Foley directed one episode of Felicity, called "The Graduate", and one episode of Monk, called "Mr. Monk and the Employee of the Month", in season 3. In addition, he had a starring role as Sergeant First Class Bob Brown in the CBS military drama The Unit, during its four-season run, and directed one episode. He guest-starred as a drug-addicted baseball pitcher on House. He also produced the sitcom A.U.S.A., on which he appeared.
Foley appeared in three episodes of ABC's comedy Cougar Town. He signed on to play a businessman being shown houses by the show's resident real estate agent, Jules, played by Courteney Cox, reuniting with her nine years after Scream 3. Foley and Cox's characters began dating, but it ended quickly.
After appearing on Shonda Rhimes' Grey's Anatomy, Foley appeared as a guest star on the second season of her hit show Scandal as Captain Jake Ballard. Later that year he was added as a regular to the cast.
Foley made his feature film writing and directing debut in 2013 with Let's Kill Ward's Wife. Foley's wife, Marika Domińczyk, and his brother-in-law Patrick Wilson star in the film, along with Donald Faison, Amy Acker and Nicollette Sheridan.
On October 19, 2000, Foley married actress Jennifer Garner, whom he met when she guest-starred on Felicity. Foley and Garner separated in March 2003 and Garner filed for divorce in May 2003.
Foley became engaged to actress Marika Dominczyk in 2006, and in June 2007, the two wed in a private ceremony in Hawaii. They have three children: daughter Malina and sons Keller and Konrad. Through that marriage, he became the brother-in-law of actress Dagmara Dominczyk, his wife's sister, who is married to the actor Patrick Wilson.
In episode 2 season 7 of the genealogy reality program Who Do You Think You Are?, it was revealed that Foley had an ancestor, Samuel Wardwell, who was a defendant in the Salem witch trials. Another ancestor, Simon Wardwell, was a member of then General George Washington's "Life Guard" during the Revolutionary War.
- Dawson's Creek
- Scream 3
- The Unit
- Grey's Anatomy
- Scott's mother died when he was 15, which changed his relationship with his father. They were a lot closer before her death.
- He used to work at Mrs. Fields Cookies. Scott was so broke at the time, he pretty much lived on left over cookies.
- He speaks fluent Japanese.
- He has lived all over the world, including Tokyo, Japan, where he lived for 4.5 years, and Sydney, Australia where he lived for 3 years.